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The researcher Asma’a Jamal Mohamed, Master student from College of Education for Pure Sciences at Tikrit University, concluded in her study entitled (Determination of oxidative stress and Prostate-specific antigen in women with breast cancer in Kirkuk city) that there is a significant increase in the concentration of Malondialdehyde in patients compared with the control group; and there is a significant decrease in groups that were treated surgically and chemically compared with patients group. In addition, there is a significant increase in groups of control and chemotherapy inpremenopause stage compared with groups in postmenopause stage.

The research results also showed a significant decrease in the concentration of Glutathione and effectiveness of Glutathione peroxidase, Catalaseand Superoxide dismutasein women with breast cancer compared with the control group. We noticed a decrease in groups that were treated surgically and chemically compared with patient group. The results also indicated a decrease in most groups in postmenopause stage compare with groups in premenopause stage. Moreover, the study showed that there is an insignificant increase in vitamin D level in patients compared with control group; and a significant increase in the group that was treated surgically and a significant decrease in chemically-treated group compared with patients group; as well as a significant decrease in healthy, patient, and surgically-treated groups and a significant increase in chemically-treated group in postmenopause stage compared with premenopause stage.

On the other hand, the results of correlations indicated that Prostate-specific antigen has a negative relationship with enzymatic and non-enzymatic antioxidants, but it has a positive relationship with Malondialdehyde and vitamin D in both control and patient groups. The current study results revealed that the association of Prostate-specific antigenlevel with breast cancer and its treatment could be an indicator for detection of breast cancer or to distinguish between benign and malignant tumors. In addition, the surgical treatment and chemotherapy have an important role in improving the oxidative stress variables under study; as well as the concentration of Prostate-specific antigencan be an indicator of oxidative stress case.

The researcher Asma’a Jamal confirmed that her research has aimed at determining the oxidative stress and Prostate-specific antigen in women with breast cancer in Kirkuk city and those patients who were treated surgically and chemically in both premenopause andpostmenopause stages. She indicated that the study was conducted in Oncology Center in Kirkuk city for the period from October 2017 till March 2018. It consisted of 60 samples of women with breast cancer whose ages ranged between 20-80 years. They were divided into three groups, each with 20 women with breast cancer who have been diagnosed based on the tests of health staff represented by Ultra Sound, Mammogragh as well as Fine Needle Aspiration-FNA. The first group included patients with breast cancer diagnosed recently and did not undergo any type of treatment. The second group included patients with breast cancer and undergo surgical treatments but did not undergo chemotherapy. The third group included chemically-treated group. The study also included 20 samples of healthy women considered as control group. Each group also distributed into two groups according to age to determine the premenopause andpostmenopause stages. The results of the current study showed a significant increase (P < 0.05) in the concentration of Prostate-specific antigen in women with breast cancer compared with the control group and a significant decrease in surgically and chemically treated groups compared with patients group; as well as a significant decrease in all groups in postmenopause stage compared with groups in premenopause stage.